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Opin., 18: 172-175

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Lipoic acid shows antioxidant activity in vitro, and the intravenous form has been used to treat diabetic neuropathy in some countries (e.g., Germany)

In the substrate oxidation stress test, the cells were prepared as above prior to the assay, and the cells were subjected to (in sequence, in final concentrations): (1) 0, 4 mM l-glutamine (Seahorse Bioscience, Billerica, MA, USA), 40 M Etomoxir (11969, Cayman Chemical, Ann Arbor, USA) or 3 M BPTES ((bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide)

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Mtraux et al., 1990