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Science 344 , 1252304 (2014)

Allowing hexokinase to operate without substantial negative feedback inhibition by its product is of paramount importance for tumors 85

Key Research Areas Key Research Areas These applications reflect ongoing scientific investigations and are provided strictly for laboratory context

The downregulation of SOD and upregulation of genes like MPO and HIF1 support this oxidative stress-driven mechanism

Somalogic probe validation Somalogic has analysed close to 1 million samples with their technology at the time of this publication, resulting in some 700 publications ( There is minimal replicate sample variability 64,65 (coefficient of variation, CV)

S-COMT is found in the liver, intestine and kidney (Taskinen et al., 2003), whereas the MB-COMT is more highly expressed in the central nervous system (Tunbridge et al., 2006)