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Damaged mitochondria trigger OS, inducing Tau aggregation, which in turn hinders selective degradation of dysfunctional mitochondria (Kerr et al., 2017)

Pese a la vida media corta en plasma, los efectos biolgicos posteriores persisten en el tejido durante mucho ms tiempo, lo que es coherente con una cascada de sealizacin en lugar de una actividad dosis-respuesta directa

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429 Addressing this constraint, the development of a recombinant urate oxidase, rasburicase and pegloticase has shown superior efficacy in rapidly reducing uric acid plasma concentrations compared to allopurinol

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doi: 10.1073/pnas.0607661103 57 RandlePJGarlandPBHalesCNNewsholmeEA