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Description

Most disease-causing mutations in these proteins occur in low-complexity domains mediating liquid-liquid phase separation to alter protein conformation, which promotes the aggregation and disrupts RNA regulation while also generating additional toxicity

Images were obtained with a transmission electron microscope (Hitachi, Japan)

Preclinical studies have indicated that these compounds markedly improve intervertebral disc structure and suppress inflammatory responses in animal models of IDD, highlighting their potential clinical applications (47,88)

Astrocytes in the epileptic brain

The most abundant C-terminal truncations is the absence of Leucine (Leu) residues, which often reduce albumin stability and shorten its half-life (Table I) (105)