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Hepatoprotection and neuroprotection induced by low doses of IGF-II in aging rats

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based on an adult requiring 2.4 mcg/day this provides the equivalent of 417 days of B12

This mechanistic distinction means the compound could theoretically be combined with appetite-suppressing peptides for a protocol that simultaneously reduces energy intake (GLP-1) and restores adipocyte energy expenditure (NNMT inhibition) though this remains purely theoretical without published combination data

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5-Amino-1MQ supports fat loss by inhibiting NNMT, an enzyme that plays a role in slowing metabolism and promoting fat storage