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In response to reduced macrophage infiltration, the mRNA expression levels of interleukin-1 ( IL1B ) tended to decline in the Luseo group compared to those in the vehicle group (Supplementary Fig

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miRNAs are small (2023-nucleotides), endogenous, single-stranded noncoding RNAs that regulate gene expression by pairing to sequence-specific binding sites in mRNAs to direct post-transcriptional repression and consequent inhibition of protein translation or degradation of the mRNA targets [179,180,181]

Diseases associated with glutathione depletion include neurodegenerative disorders (Alzheimers, Parkinsons, Huntingtons diseases, amyotrophic lateral sclerosis, Friedreichs ataxia), pulmonary disease (COPD, asthma, and acute respiratory distress syndrome), immune diseases (HIV, autoimmune disease), cardiovascular diseases (hypertension, myocardial infarction, cholesterol oxidation), chronic age-related diseases (cataracts, macular degeneration, hearing impairment, and glaucoma), liver disease, cystic fibrosis and the aging process itself