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Direct contact between the peptide and esophageal tissue during swallowing provides local exposure in addition to systemic effects achieved after absorption

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This peptide also stimulates expression of growth factors including VEGF (vascular endothelial growth factor) and EGF (epidermal growth factor), which in rat studies correlated with enhanced angiogenesis

Dominant negative G s (DNG s ) in pFastBac vector, and poly-his tagged G1 and G2 in a single pVL dual vector construct were used as previously described

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