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Elevated oxidative stress fosters the proliferation and hypertrophy of vascular smooth muscle cells, as well as collagen deposition, culminating in vascular medial thickening and constriction

if the medication accidentally freezes during shipping or storage, it may form crystals or cloudiness

The consequences of NNMT inhibition over months or years are unknown

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In clinical trials at the 12 mg dose, researchers documented nausea in 28% of participants, diarrhea in 23%, constipation in 17%, and vomiting in 12%