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For patients receiving intramuscular B12 injectionsthe standard treatment for pernicious anaemia and severe deficiency neurological symptoms may start improving within one to two weeks , whilst haematological parameters typically normalise within approximately eight weeks

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Additionally, certain medications and genetic predispositions can increase susceptibility to developing hyperpigmentation, making it a multifaceted concern requiring targeted treatment approaches

et al., 2023) the cAMP/PKA/p-CREB pathway was altered in the amygdala alongside neuronal apoptosis (Jiang et al., 2023), and cortical cytokinesincluding IL-1, IL-6, and TNF- were elevated (Wang J

Garza, K

Lei Y, Wang J, Wang D, Li C, Liu B, Fang X, et al