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Abbreviations BCAA: Branched-chain amino acid BMI: Body mass index CNT: Healthy control HOMA-IR: Homeostatic model assessment for insulin resistance PO: Parental obesity PO + : Children with obesity born to parents with obesity PO : Children with obesity born to parents without obesity References Lin X, Li H

Consistency, more than any other single factor, determines whether a tirzepatide protocol delivers the results shown in clinical trials

Conclusion LSG in children with obesity induces an improvement of MAFLD-related metabolic derangement and liver damage, but also a mild hyperhomocysteinemia that should be avoided to prevent cardiovascular risk