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Glioma Tumor cells may acquire resistance to therapies, leading to stress-induced autophagy activation that promotes tumor growth and recurrence [3, 204]

Aggresome contents eventually can undergo lysosomal degradation via autophagy

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Notably, PGE2 suppresses the activation and activity of T cells by enhancing PD-L1 expression and the polarization of TAMs through cAMP and mitochondrial signals, thereby forming a positive feedback cycle [62, 63]

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For this reason, there have been no reported investigations of the skin-whitening effect of GSH in topical formulations, unlike in oral formulations