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In addition to oxidative stress, excessive copper ion accumulation alters energy metabolism patterns within cardiomyocytes by inducing abnormal aggregation of thioctylated proteins and loss of iron-sulfur cluster proteins in the respiratory chain complex through direct binding to thioctylated proteins in the mitochondrial TCA cycle (76)

1993;32(13):3368-3376.[DOI] 20

The animal was placed on a stereotaxic frame to perform a left craniotomy

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