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GRKs phosphorylate activated GPCRs, leading to the recruitment of arrestins

The intertwined dysregulation of copper and iron metabolism further exacerbates the disease by promoting apoptosis in lipid-rich foam cells and VSMCs, which are particularly vulnerable to metal-dependent cell death [195, 196]

The fact that, like these women [10, 13, 81], the mouse model had smaller ovarian reserves, later pubertal onset and possibly lower ovulatory rates, and that this gene encodes a widely-expressed steroidogenic enzyme with key roles in the HPG axis, led us to hypothesize that the SRD5A1 downregulation might mediate the effect of the early-life events on these characteristics, and the mouse model enabled us to examine its role in the central control of reproduction in vitro and in vivo

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The primary sleep-related mechanism of Epitalon is its direct influence on melatonin synthesis