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The primary outcome was a composite endpoint of all-cause mortality, decompensation of cirrhosis (ascites, variceal haemorrhage, hepatic encephalopathy), hepatocellular carcinoma, liver transplantation or progression to a model of end stage liver disease score 15

Arginase inhibition suppresses lung metastasis in the 4T1 breast cancer model independently of the immunomodulatory and anti-metastatic effects of VEGFR-2 blockade