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Roman E, Cordoba J, Torrens M, et al

However, 3T3-L1 preadipocytes treated with LA exhibit lower insulin-induced differentiation by modulating activity and/or expression of various anti-adipogenic transcription factors mainly through activating the MAPK pathways that negatively regulate PPAR and C/EBP [141]

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In diabetes, diminished abundance of Akkermansia , Bacteroides , Bifidobacterium , Faecalibacterium , and Roseburia reduces -glucuronidase and 7-dehydroxylase activities, thereby blocking the conversion of primary BAs to secondary BAs and consequently decreasing the synthesis of DCA and LCA (Li et al., 2021b)

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