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Deviations from these methylation patterns can lead to gene abnormalities or even genomic instability, resulting in uncontrolled cellular behavior, which is significantly associated with the development of tumors

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J Neuroimmunol 34:159164 Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD (2016) A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms

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24 Diabetes alters the balance between the oxidant-antioxidant system by increasing ROS as well as compromising the antioxidant defense system