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J Pharmacol Exp Ther (1991) 257:66875

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2011(1):CD003648

Second, the successful clinical translation of SFN depends fundamentally on overcoming the substantial interindividual variability in its bioavailability and metabolism

For instance, in melanoma patients receiving immune checkpoint inhibitor therapy, those with increased TCR clone diversity after treatment experience an approximately 30% higher objective response rate (ORR) compared to patients without an increase