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Additionally, production of multiple -lactamases has been shown to contribute to the emergence of cefiderocol non-susceptibility in several Gram-negative isolates (Kohira et al., 2020)

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Precipitation of proteins leads to necrosis and destruction of epidermis, followed by inflammation and activation of wound repair mechanisms

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The methylated ring nitrogen gives the molecule a positive charge

Young LN, Cho K, Lawrence R, Zoncu R, Hurley JH (2016) Dynamics and architecture of the NRBF2-containing phosphatidylinositol 3-kinase complex I of autophagy