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To address these gaps, future research should prioritize larger scale multicenter randomized controlled trials with standardized protocols, adequately powered biomarker-guided RCTs with harmonised clinical endpoints plus GSH/GSSG, MDA/TBARS, SOD/CAT/GPx panels, head-to-head monotherapy vs

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Kashyap MP, Khan J, Sinha R, Jin L, Atigadda V, Deshane JS, et al

Abatacept for treatment-refractory pediatric CTLA4-haploinsufficiency

229 This platform exploits overexpression of the protease furin in the tumor microenvironment to trigger in situ nanoparticle aggregation, enhancing tumor retention via the enhanced permeability and retention (EPR) effect