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Highlights: GSH is crucial for cellular redox balance across various organelles

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has demonstrated that in case of cervical cancer, miR-1468-5p, a cancer-secreted exosome-encapsulated miRNA, promotes lymphatic PD-L1 upregulation and lymphangiogenesis, ultimately resulting in the impairment of lymphocyte T function

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Collectively, these clinical data substantiate the SNHG9 MAS regulatory axis and suggest that MAS upregulation during DILI may represent an adaptive response aimed at promoting hepatoprotective forms of autophagy, including mitophagy, thereby preserving hepatic homeostasis under hepatotoxic stress

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