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In the first clinical study on BBB disruption using LITT, the permeability of the BBB increased after hyperthermia, with higher permeability peaking a few days to a few weeks after the procedure 119

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Additionally, double-stranded RNA-activated protein kinase (PKR) has been identified as a key transducer of inflammatory signals in colonic epithelial cells

Interaction effects are highly informative for interpreting treatment responses, and therefore, main effects are not separately reported