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Mechanistically, in contrast with the canonical doctrine that GSH globally maintains proteins in a reduced state, we show that GSH depletion selectively oxidizes and promotes the degradation of fatty acid synthase (FASN), a key regulator of lipid metabolism

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GPX: glutathione peroxidase

Cancer Res 56(13):3010-20, 1996

10.1038/jhg.2014.41 J

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Furthermore, modulation of Glo-I activity with the anti-inflammatory drug ethyl pyruvate (EP) was performed to analyze impact of Glo-I in initiation and progression of cirrhosis