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Conclusion Astrocytes are a fundamental cell type in the brain and are involved in supporting neurons through the regulation of metabolic pathways, ion signaling cascades, clearance of toxic molecules and initiation of BBB formation

Thus, we investigated the clonogenic survival of SCC-61, rSCC-61, and MTHFD2 knockdown rSCC-61 cells treated with MTX and CB83, an irreversible inhibitor of the PPP rate-limiting enzyme G6PD ( Figures 3E, F )

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It is the most popular skin lightening agent in Japan because of its ability to inhibit melanin production by inhibiting tyrosinase activity

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