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Now the other thing I'd add number six to the assumptions is assume everybody has some degree of leaky gut

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( B ) Hb levels and reticulocyte count in 4.2 / mice treated with vehicle or mitapivat (100 mg/kg/d) or splenectomized (spleenx) monitored up to 7 months of age

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10d,e) and still showed extremely prolonged prothrombin times (a parameter of vitamin K-dependent coagulation factors) in contrast to Fsp1 +/ mice (Fig