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doi: 10.1016/j.ejca.2021.03.009 59 SubramaniamSSelvadurayKRRadhakrishnanAK

10.1023/a:1011927812753 131 SunT.-L.LiuZ.QiZ.-J.HuangY.-P.GaoX.-Q.ZhangY.-Y

(A) Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master transcription factor for the antioxidant system

Translation is limited at present by on-target injury in normal tissues and by off-target pathway perturbations, necessitating solutions that separate lesion efficacy from systemic risk