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Bupropion Bupropion is a dopamine and norepinephrine-reuptake inhibitor that has been marketed as an anti-depressant and for smoking cessation

While the mechanisms behind this ultra-short CR intervention are not fully understood, it is a relatively simple approach that warrants further investigation

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Potentially deleterious reactive oxygen species (ie, superoxides, peroxides, and hydroxyl radicals) are produced during the oxidation of fuels (oxidative phosphorylation) in mitochondria as byproducts of the utilization of molecular oxygen in the electron transport chain

Excretion is presumed to occur primarily through renal and hepatic routes, based on typical peptide pharmacokinetics

However, overexpression of -syn interferes with this process