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(jofem.org) The best-case signal: modest weight loss in a shorter trial A frequently cited 12-week randomized trial result (as summarized in reviews) reported: ~2.6 kg average loss with AOD-9604 1 mg/day vs ~0.8 kg with placebo (PMC) This is the kind of result that can be statistically meaningful, clinically modest, and very sensitive to study design (diet, activity, baseline metabolic status, adherence)

(PubMed) Lam JR, Schneider JL, Zhao W, Corley DA

Daratumumab: a first-in-class CD38 monoclonal antibody for the treatment of multiple myeloma

Discussion We make no claim to have identified definitive an immutable criteria for the use of vitamin B12 in general practice

0.3 mL delivers the same dose at a lower concentration

Problems with analogues: Spirulina algae has not been shown to resolve B12-related problems