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280,283,284,285 Liver deficiency of YAP, or both YAP and TAZ, results in abnormalities in bile duct morphogenesis, hepatitis and fibrosis due to cholestatic injury

At the end of the experiments, the mice were killed by overdosing them with anaesthetic (isoflurane) followed by cervical dislocation

10.1093/cvr/cvt036 243 PernowJ.KissA.TratsiakovichY.ClimentB

However, some evidence suggests that CSCs amplified epigenetic changes, drug transporters, dormancy, and EMT-MET transitions that have a definite role to play in developing resistance [117, 118]