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doi: 10.1016/J.JHAZMAT.2020.124308 42

Proc Am Assoc Cancer Res 44:1488-1489, 2003

Hypoxia, via HIF-1, directly upregulates PD-L1 expression in various tumor cells by directly binding to the HRE in PD-L1 gene promoter, causing immunosuppressive TME (51, 80)

doi: 10.1097/ALN.0b013e3182834d94 46 DenH.DongX.ChenM.ZouZ

Zhou Q, Meng Y, Li D, Yao L, Le J, Liu Y, Sun Y, Zeng F, Chen X, Deng G (2024) Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies