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The contrast with prescriptions for oral medications is particularly sharp and underscores the patients feeling of being uniquely constrained

The Neelakantan 2018 paper showed strong oral absorption in cell uptake (Caco-2) assays, which is why most research community use is by mouth instead of by injection

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The 2021 fifth edition of the WHO Classification of CNS Tumors categorizes MBs into four distinct molecular subgroups: WNT-activated, SHH-activated with TP53 wild type, SHH-activated with TP53 mutation, and non-WNT/non-SHH (formerly classified as groups 3 and 4 (50, 5860)

Adding too much water dilutes the medication, meaning you will need to draw up a larger volume of liquid into your syringe to get the same milligram dose