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Among the different glial cell types, the oligodendrocyte lineage appears to be the least capable of repairing DNA damage

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Radiotherapy inhibits tumor growth by generally inducing tumor cell apoptosis, necrosis, mitotic catastrophe, autophagy, or senescence through inflicting extensive DNA damage, including DNA-protein crosslinking, or transiently increasing the levels of cytotoxic reactive oxygen species (ROS) (Kim et al., 2015)

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