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In CRC, EZH2 suppresses the upstream mTOR inhibitors TSC2, RHOA, DEPTOR , and FKBP11 by recruiting MTA2 and increasing H3K27me3 at their promoters, thereby activating mTOR signaling and inhibiting autophagy

(PUBMED: Reference #1, Reference #2, Reference #3) B12 is added to alleviate the nauseous side effects that Tirzepatide can have on some patients

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