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The effect of an adenosine A2A agonist on intra-tumoral concentrations of temozolomide in patients with recurrent glioblastoma

Nature 2004

Preclinical studies that combine disease-relevant models with spatial readouts of drug distribution and pathology can therefore provide important insight into whether a therapeutic strategy is likely to translate into meaningful CNS efficacy

That makes cagrilintide less of a direct competitor and more of a potential alternative for people whose bodies dont respond well to GLP-1 therapy, or who struggle with its side effects