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There are also management fees and other expenses associated with the funds in your portfolio (as explained in each funds prospectus in the fees and expense section)

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The fact that it showed significant neuroprotection when administered just 30 seconds after ischemia suggests a rapid mechanism of action, which is critical in the narrow therapeutic windows that characterize acute brain injury

First-Pass Elimination Following absorption across the gut wall, the portal blood delivers the drug to the liver prior to entry into the systemic circulation

& Papanastasiou, G