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FIGURE 1 2.2 GSHs role in brain-resident immune cells In the CNS, GSH protects mitochondrial function, prevents lipid peroxidation, and maintains the redox state of cysteine residues in proteins
Do not mix different peptides in the same syringe or vial
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Abbreviations 95% CI: 95% Confidential interval AEs: Adverse events AIC: Akaikes Information Criterion ALT: Alanine aminotransferase aPTT: Activated partial thromboplastin time BHMT: Betaine-homocysteine methyltransferase BMI: Body mass index B12: Vitamin B12 CBS: Cystathionine beta-synthase CT: Computed tomography DHFR: Dihydrofolate reductase ECOG-PS: Eastern Cooperative Oncology Group performance status FA: Folic acid FN: Febrile neutropenia FPGS: Folylpoly--glutamate synthase G: Grade GGH: -Glutamyl hydrolase Hcy: Homocysteine HIBCH: 3-Hydroxyisobutyryl-CoA hydrolase HR: Hazard ratio LD: Linkage disequilibrium MPM: Malignant pleural mesothelioma MTHFR: Methylenetetrahydrofolate reductase MTR: Methionine synthase MTRR: Methionine synthase reductase NLR: Neutrophil to lymphocyte ratio non-Sq NSCLC: Non-squamous non-small cell lung cancer OR: Odds ratio OS: Overall survival PFS: Progression-free survival PS: Propensity score PT: Prothrombin time RBC: Red blood cell RBP: Retinol-binding protein ROC: Receiver operating characteristics SI: Smoking index SLC19A1: Folate carrier SNPs: Single-nucleotide polymorphisms Tf: Transferrin TTR: Transthyretin TYMS: Thymidylate synthase References Niyikiza C, Hanauske AR, Rusthoven JJ, Calvert AH, Allen R, Paoletti P, et al
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