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Key Nutrients for B12 Kidney Safety: Folate (400-800mcg): Prevents homocysteine buildup B6 (25-50mg): Supports the methionine cycle B2 (10-25mg): Helps make the enzymes B12 needs Magnesium (200-400mg): Activates B12-related enzymes Zinc (15-30mg): Helps transport B12 around your body The Minerals That Often Get Forgotten Certain minerals can either help B12 work better while protecting your kidneys, or make potential problems worse when youre deficient

During the initial treatment of patients with pernicious anemia, serum potassium must be observed closely the first 48 hours and potassium replaced if necessary

B12 deficiency can result from dietary factors such as a lack of animal products or from conditions affecting absorption like pernicious anaemia or gastrointestinal surgery

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If you're in UK, I recommend reading all these documents below UK B12 documents BSH Cobalamin and Folate Guidelines b-s-h.org.uk/guidelines/gui