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In addition, the diagnosis of discogenic LBP is intrinsically challenging as many patients suffer from LBP in absence of radiological signs of IDD, as well as many others who show even mildadvanced IDD at MRI but are completely asymptomatic

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599 The interlaminar astrocytes (which populate brains of high primates and are not present in other species 32,33 ) are highly vulnerable to AD pathology: at the advanced stages of the disease interlaminar astrocytes disappear, 600 although how this impacts on the disease pathophysiology remains unknown

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Severe deficiency symptoms include vitamin E deficiency-induced ataxia, peripheral neuropathy, muscle weakness, and damage to the retina of the eye

Opioid Analgesic Risk Evaluation and Mitigation Strategy (REMS): To ensure that the benefits of opioid analgesics outweigh the risks of addiction, abuse, and misuse, the Food and Drug Administration (FDA) has required a Risk Evaluation and Mitigation Strategy (REMS) for these products