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Indeed, increased Hcy and decreased vitamin B12 were observed in mothers of neonates with NTD and in neonates with NTD [103]

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However, in other parts of the brain with high NMDA receptor expression, like the hippocampal formation (Monyer et al., 1994), responses mediated by strychnine-sensitive glycine receptors are absent, at least in adult neurons, indicating the lack of glycinergic inhibitory neurotransmission (Ito and Cherubini, 1991)