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The core objective of these strategies is to address the complex, multi-system pathological mechanisms of PD, aiming to achieve superior overall efficacy compared to single-target therapies through synergistic interventions at different pathological nodes

PLoS ONE 11(6):e0158227 Mahmood RT, Shamim A, Ahsan F, Parveen S (2021) Foeniculum vulgare , solanum nigrum and cichorium intybus : a collectanea of pharmacological and clinical uses

Chlorophylls, nonetheless, exert potent reactive oxygen species scavenging effects, as described in detail for chlorophyllin, a water-soluble analog of chlorophylls.17 Since the cell proliferation is strongly influenced by redox signaling,18 this antioxidant action of chlorophylls might account for their presumed anti-proliferative properties

In contrast, inhibition of miR-424-5p can enhance the sensitivity of OC cells to ferroptosis (117)

The roles of glutathione in the apoplast still have to be clearly dissected but seem to involve sensing and signaling stress conditions rather than the plain detoxification of ROS