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While inhibition of COX-1 can have serious gastrointestinal consequences, selective inhibition of COX-2 carries cardiovascular risks

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As a result, diverse glial immune responses and microbiota configurations may have emerged, leaving lasting biological imprints that could represent the evolutionary origins of aging and disease

Nature 436, 112116

Additionally, the HNF4 agonist NCT was administered via IP injection for 7 days, with 1 injection during the first 3 three days, 2 injections during the following three days, and 1 injection on the day of CLP, at a dose of 200 mg/kg, dissolved in DMSO