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On one hand, gut dysbiosis facilitates ferroptosis by affecting iron metabolic pathways, like blocking the synthesis and release of hepatic hepcidin and expression of the iron transporter FPN1 to inhibit iron efflux and causing systemic and local iron overload in joints, thus leading to ferroptosis in OA chondrocytes

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Conflict of interest Aleksandra Biaczyk, Adam Weniak, Barbara Kamiska and Rafa Czajkowski have no conflicts of interest that are directly relevant to the content of this article