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Thus, conditioned-media approaches can support metabolite screening but cannot replace direct Gut-on-a-Chip co-culture for modeling microbiome-dependent first-pass metabolism

Payers evaluate clinical appropriateness against coverage criteria including diagnosis, prior treatment failures, and prescriber specialty qualifications

170 Several inhibitors are under development, one of which has entered clinical trials, but no effective anti-inflammatory effect has been demonstrated

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Mizuno Y, Yamamoto M, Kuno S, Hasegawa K, Hattori N, Kagimura T, Sarashina A, Rascol O, Schapira AH, Barone P, Hauser RA, Poewe W