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[DOI] [PMC free article] [PubMed] [Google Scholar] Hozo 2005 Hozo SP, Djulbegovic B, Hozo I

IGF1 promotes human myotube differentiation toward a mature metabolic and contractile phenotype

Its molecular weight is far smaller than traditional peptides

Mechanism of Action Inhibits Nicotinamide N-Methyltransferase (NNMT) Increases intracellular nicotinamide and NAD levels Improves mitochondrial efficiency and energy metabolism Supports lipolysis and fat oxidation Reduces adipocyte (fat cell) growth and proliferation Modulates inflammatory pathways and insulin signaling These effects may lead to enhanced fat metabolism, better blood sugar regulation, improved endurance, and a general increase in metabolic flexibility

This is why the two are better understood as complementary research subjects than as comparable ones: Tesamorelin research maps onto the endocrine and hormone-axis literature, while MOTS-c research maps onto the mitochondrial and cellular-energy literature

Improving levels may help emotional stability and wellbeing. 9