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Extensive crosstalk exists between oxidative and ER stress as oxidative stress can disrupt redox homeostasis in the ER, triggering ER stress (95)

Epigenetic mechanisms, such as DNA methylation, mediate the regulation of gene expression by environmental factors

The siRNA encapsulation efficiency was greatly affected by the change of the DSPC to DOPE, whereas DOPE allowed a consistently high encapsulation efficiency with up to 70 % of ionizable lipid molar ratio, while the encapsulation efficiently greatly dropped under similar conditions while using DSPC (Leung et al., 2015)

From a kinetic perspective, many nanozymes deviate from conventional enzymatic models due to their multi-site, multifunctional, and multi-substrate characteristics, necessitating tailored kinetic frameworks to accurately describe their catalytic behavior

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Additionally, investigating the long-term effects of MSM on metabolic parameters and liver function will be crucial for establishing its clinical relevance