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Chemosphere, 144 , 138147

Curcumin is often described as a hormetic compound because it induces an adaptive stress response: it mildly stresses cells in ways that activate Nrf2 and other transcription factors, leading to increased production of antioxidant and cytoprotective proteins (e.g., heme oxygenase-1) that precondition cells against subsequent injuries (77, 78)

These extremely low GA infants may not have surfactant deficiency or RDS but instead have early requirements for oxygen and ventilatory support due to multiple factors leading to respiratory instability of prematurity 127,128,129

Since both cell types were more sensitive to CuCl 2 treatment, it was used for subsequent experiments

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This method bypasses the digestive system, leading to higher bioavailability compared to oral supplements, which can be degraded by stomach acids and enzymes, resulting in reduced absorption