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Certain secondary metabolites produced by microorganisms may influence host physiological functions, such as modulating the proliferation of rumen epithelial cells, regulating fermentation patterns, affecting appetite, or participating in immune regulation [51]

Associated with the circadian disruption is the activation of mast cells by inflammatory cytokines .[ref] So it is a two-hit scenario: circadian rhythm disruption in mast cells along with elevated inflammatory cytokines