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So a definition such as the one above can be unrolled into several different linear sequences of KOs, each of which we consider to be a possible path through the module

DSS-induced colitis in mice elicited pronounced symptoms, including reduced locomotor activity, decreased consumption of food and water, dull and lifeless fur, signs of depression-like behavior, huddling behavior, perianal swelling and congestion, diarrhea, bloody stools, and substantial weight loss

In addition, since the known effect of oxidative stress in MDD pathophysiology and the frequent MDD comorbidity in OCD may be a confounding factor in our data, we aimed to compare OCD patients with and without MDD comorbidity within themselves and with healthy controls in this study

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Over-dilution problems Adding too much water creates a solution so dilute that practical dosing becomes difficult or impossible