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doi: 10.3389/fimmu.2026.1736082 Received 30 October 2025 Revised 06 March 2026 Accepted 09 March 2026 Published 26 March 2026 Volume 17 - 2026 Edited by Christian David Sadik, University of Lbeck, Germany Reviewed by Samanta Celeste Funes, CONICET Multidisciplinary Institute of Biological Research of San Luis (IMIBIO-SL), Argentina Igbayilola Yusuff, Baze University, Nigeria Updates Copyright 2026 Yin, Yan, Pei, Rao, Wu, Xue, Sun and Sheng

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Whilst B12 plays an essential role in energy metabolism, red blood cell production, and nervous system function, there is no evidence that supplementation increases energy in individuals with normal B12 status