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Advanced biotechnology and nanomedicine are required for all of these, which still faces certain technical challenges

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Common indicators include: Fatigue and Weakness: Persistent tiredness and low energy are often the first signs of low vitamin D

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However, population-based studies performed in Catalonia and the Canary Islands [7, 8], both of which used a serum vitamin B12 cut-off of 200 pg/ml, returned values of 1.9% and 3.4% respectively