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conducted a 12-week facial study on 67 women and reported that GHK-Cu cream applied twice daily improved aged skin appearance, increased thickness, reduced wrinkles and strongly stimulated dermal keratinocyte proliferation as determined by histological analysis of biopsies

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The temperature was set at 310 K, using a thermostat damping of 0.1 ps 1 and the M-SHAKE algorithm 53 to constrain the bond lengths involving hydrogen atoms

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